The Ford Piquette Avenue plant is a major national landmark and is of international historic significance.

The Model T has been voted the most important car of the 20th Century. Henry Ford's "universal car" put personal transportation within reach of the average citizen and thereby "put America on wheels." Key techniques for the automotive assembly line were developed at this site.

A record for car production was achieved at the Piquette Plant, thereby firmly establishing American expertise in automobile manufacturing. Ford Motor Company became the largest American manufacturer of cars while at Piquette.

In recognition of this historical importance, the Ford Piquette Avenue plant is on the National Register of Historic Places. It is a State of Michigan Historic Site and a City of Detroit Historic District.

In February 2006, the plant was designated a National Historic Landmark. National Historic Landmarks are nationally significant historic places designated by the Secretary of the Interior because they possess exceptional value or quality in illustrating or interpreting the heritage of the United States. Fewer than 2,500 historic places bear this national distinction. Other National Historic Landmarks in the City of Detroit include the Fisher Building, Fox Theater, General Motors Building (now Cadillac Place), and the Guardian Building.